An infant with lamellar ichthyosis presenting with meningitis.

Lamellar ichthyosis is a rare congenital disorder characterized by widespread epidermal hyperkeratinization. It is a rare clinical disorder throughout the entire planet, and newborns with this disease frequently have collodion membranes (adhering, supple, parchment-like membrane). We present a 45-day-old infant who came to our facility complaining of a high-grade persistent fever, high-pitched crying, decreased feeding, odd body movements, rapid breathing, and grunting that lasted for 2 days. He was diagnosed with lamellar ichthyosis.